Characteristic | Description |
---|---|
Active Ingredient | Sildenafil |
Available Dosages | 20 mg |
Primary Use | Pulmonary Arterial Hypertension |
Administration Route | Oral |
Formulation | Tablets |
Pharmacokinetics | Rapid absorption, hepatic metabolism, renal excretion |
Learn More About Revatio |
Pharmacokinetics
Sildenafil, the active ingredient in Revatio 20 mg, is rapidly absorbed after oral intake. Peak plasma concentrations occur within 30 to 120 minutes. The drug’s bioavailability is approximately 41%, affected by first-pass metabolism in the liver. Food can delay absorption, extending the time to reach peak plasma levels. However, the overall exposure remains unchanged. Metabolism occurs primarily through cytochrome P450 enzymes CYP3A4 and CYP2C9. The major circulating metabolite, N-desmethylsildenafil, also possesses pharmacologic activity. Renal clearance contributes minimally to sildenafil’s elimination, with most excretion via feces as metabolites.
Other uses for Revatio
While Revatio 20 mg is primarily prescribed for pulmonary arterial hypertension (PAH), its active component, sildenafil, is more widely known for treating erectile dysfunction (ED). Although these uses require different dosages, the mechanism of action remains consistent. By inhibiting phosphodiesterase type 5 (PDE5), sildenafil promotes vasodilation and improved blood flow. Off-label, sildenafil may also address conditions like Raynaud’s phenomenon and high-altitude pulmonary edema. These alternative applications leverage sildenafil’s vascular effects, benefiting patients with various circulatory disorders.
Revatio Contraindications
Revatio 20 mg is contraindicated in patients with known hypersensitivity to sildenafil or any excipients in the formulation. The drug should not be used concomitantly with nitrates or nitric oxide donors, as this combination can cause severe hypotension. Patients with severe hepatic impairment or retinitis pigmentosa should avoid Revatio due to potential risks. Caution is advised in individuals with a history of stroke, myocardial infarction, or life-threatening arrhythmia. Healthcare providers must evaluate these factors before prescribing Revatio, ensuring safe and effective treatment.
Cautions with other medicines
Several drug interactions can impact the safety of Revatio 20 mg. Concomitant use with strong CYP3A4 inhibitors like ketoconazole can increase sildenafil’s plasma concentration. This may enhance adverse effects. Caution is also necessary when Revatio is combined with alpha-blockers. This combination can lead to symptomatic hypotension in some patients. Rifampin, a CYP3A4 inducer, may decrease sildenafil levels, potentially reducing its efficacy. Close monitoring and dosage adjustments can help mitigate these risks.
Adverse Effects
Common side effects of Revatio 20 mg include headache, flushing, dyspepsia, and nasal congestion. These are generally mild and transient. More serious adverse events, such as sudden vision loss or hearing impairment, require immediate medical attention. Priapism, a prolonged and painful erection, is a rare but serious condition associated with sildenafil use. Patients experiencing this should seek urgent care. Balancing therapeutic benefits against potential risks is essential in managing treatment with Revatio.
Revatio Over The counter
Revatio 20 mg is not available over the counter. It requires a prescription due to its pharmacological profile and potential interactions. The need for medical oversight in its use is critical. Self-medicating with sildenafil, especially from unregulated sources, poses significant health risks. Patients should consult healthcare providers to ensure appropriate use. A thorough assessment can guide safe and effective treatment strategies, enhancing patient outcomes while minimizing potential harms.
Data source:
- https://phone-internet.us/infections-from-a-medical-perspective/
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- https://emelydesign.com/2024/01/03/lesiones-infantiles-y-avances-en-vacunacion/
- https://accionesparaganar.com/comprender-el-impacto-del-fenproporex-en-la-ictericia-y-el-kernicterus-en-recien-nacidos/
- https://commersys.com/exploring-noscapine-a-new-hope-for-pigmentation-disorders/
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- https://mesinfotocopyjakarta.com/melkersson-rosenthal-syndrome/
- https://hairplus.suglex.com/mucopolisacaridosis-i/
- https://www.online360.co/stress-and-its-influence-on-modern-medicine/
- https://ithumansolutions.com/2024/07/05/calcitonins-role-in-bone-density-regulation/